Are you one of the many people in South Bay who are burning the candle at both ends and maybe only getting 4 or 5 hours of sleep a night? Are you also one of those guys having problems with his sex drive and feeling out of sorts? Well, recent studies done in South Bay in the last 3 years show that these symptoms could all be due to the effect of sleep on testosterone – just how, though, may be a chicken and egg question!
While it’s true that lower testosterone levels can be the cause of a sluggish sex drive and irritability it seems to be a matter of research opinion whether low sleep levels cause low testosterone or low testosterone causes lack of sleep.
Hormone Imbalance in Women
There's a growing interest in testosterone hormone replacement for treating symptoms related to aging. You've probably seen advertisements of virile, muscle bound men in their 60's and 70's.
Along with the growing interest there's also a growing amount of information. But much of it is anecdotal stories, misleading data and flat out, unproven myths. Especially as it relates to testosterone replacement therapy for women.
The fact is that medically administered, testosterone therapy is also used to successfully treat symptoms of hormone deficiency in pre and postmenopausal women. And two physicians-Dr. Rebecca Glaser and Dr. Constantine Dimitrakakis-are dispelling the misinformation about it through scientific research.
Dr. Glaser and Dr. Dimitrakakis focus on subcutaneously implanted, bio-identical hormones (human identical molecule) and not oral, synthetic androgens or anabolic steroids.
With that in mind, here are the 10 myths of testosterone replacement therapy for women.
Myth #1: Testosterone is a "male" hormone
Although men have a higher circulating level of testosterone than women, from a biological perspective, men and women are genetically similar. Both sexes include functional estrogen and androgen (testosterone) receptors. And while estrogen is popularly considered the primary female hormone, throughout a woman's lifespan, testosterone is actually the most abundant, biologically active hormone with significantly higher levels than estradiol. And as early as 1937, testosterone therapy was reported to effectively treat symptoms of the menopause.
Myth #2: Its only role in women is sex drive and libido
There's a lot of hype about testosterone's role in sexual function. But in reality, it's a fraction of the overall physiologic effect testosterone plays in women. That's because testosterone governs the health of almost all tissues including the breast, heart, blood vessels, gastrointestinal tract, lung, brain, spinal cord, peripheral nerves, bladder, uterus, ovaries, endocrine glands, vaginal tissue, skin, bone, bone marrow, synovium, muscle and adipose tissue.
The function of these tissues declines as testosterone declines. The result of this deficiency in both men and women includes dysphoric mood (anxiety, irritability, depression), lack of well-being, physical fatigue, bone loss, muscle loss, changes in cognition, memory loss, insomnia, hot flashes, rheumatoid complaints, pain, breast pain, urinary complaints, incontinence as well as sexual dysfunction. And just like for men, these symptoms are successfully treated in women through testosterone therapy.
Myth #3: It masculinizes females
Testosterone therapy has been safely and successfully administered in women for over 76 years. Rather than decrease a woman's femininity it increases it. Testosterone stimulates ovulation, increases fertility and safely treats the nausea of early pregnancy without adverse effects.
Sure, large doses of supra-pharmacological synthetic testosterone are used to treat female to male transgender patients to increase male traits like body hair. But this requires high doses over an extended period of time. Even then, true masculinization is still not possible. And these effects are reversible by simply lowering the dosage.
Myth #4: It causes hoarseness and voice changes
Hoarseness is most commonly caused by inflammation due to allergies, infectious or chemical laryngitis, reflux esophagitis, voice over-use, mucosal tears, medications and vocal cord polyps. Testosterone possesses anti-inflammatory properties. There is no evidence that testosterone causes hoarseness and there is no physiological mechanism that allows testosterone to do so.
Although a few anecdotal case reports and small questionnaire studies have reported an association between 400 and 800 mg/d of danazol and self-reported, subjective voice 'changes' an objective study demonstrated the opposite.
Twenty-four patients received 600 mg of danazol (synthetic testosterone) therapy daily and were studied for 3 and 6 months. There were no vocal changes that could be attributed to the androgenic properties of danazol. These conclusions are consistent with a one year study examining voice changes on pharmaco-logic doses of subcutaneous testosterone implant therapy in women by Glaser and Dimitrakakis.
Myth #5: It causes hair loss
Hair loss is a complicated, genetically determined process and there is no evidence that either testosterone or testosterone therapy cause it. In fact, from a medical perspective, dihy-drotestosterone (DHT), not testosterone, is considered the active androgen in male pattern balding.
There are many factors associated with hair loss. For example, it's common in both women and men with insulin resistance. Insulin resistance increases 5-alpha reductase, which increases conversion of testosterone to dihy-drotestosterone in the hair follicle.
In addition, obesity, age, alcohol, medications and sedentary lifestyle increase aromatase activity, which lowers testosterone and raises estradiol. Increased DHT, lowered testosterone, and elevated estradiol levels can contribute to hair loss in genetically predisposed men and women. But so can medications, stress and nutritional deficiencies.
In studies conducted by Glaser and Dimitrakakis, two thirds of women treated with subcutaneous testosterone implants have scalp hair re-growth on therapy. Women who did not re-grow hair were more likely to be hypo or hyperthyroid, iron deficient or have elevated body mass index. And none of the 285 patients treated for up to 56 months with subcutaneous T therapy complained of hair loss.
Myth #6: It has adverse effects on the heart
On the contrary, there is overwhelming biological and clinical evidence that testosterone promotes a healthy heart. Testosterone has a beneficial effect on lean body mass, glucose metabolism and lipid profiles in men and women. It is successfully used to treat and prevent cardiovascular disease and diabetes.
Testosterone also widens blood vessels in both sexes, has immune-modulating properties that inhibit plaque and strengthens the cardiac muscle. It improves functional capacity, insulin resistance and muscle strength in both men and women with congestive heart failure.
Myth #7: It causes liver damage
High doses of oral, synthetic androgens (e.g., methyl-testosterone) pass through the digestive system, are absorbed into the entero-hepatic circulation and can adversely affect the liver. But subcutaneous implants and topical patches avoid the entero-hepatic circulation and bypass the liver. So there is no adverse effect on the liver, liver enzymes or clotting factors.
Furthermore, non-oral testosterone does not increase the risk of deep venous thrombosis or pulmonary embolism like oral estrogens, androgens and synthetic progestins. And despite the concern over liver toxicities with anabolic steroids and oral synthetic androgens, there are only 3 reports of hepa-tocellular carcinoma in men treated with high doses of oral synthetic methyl testosterone. Even the report of benign tumors (adenomas) with oral androgen therapy is exceedingly rare.
Myth #8: It causes aggression
Although anabolic steroids can increase aggression and rage, this does not occur with testosterone therapy. Even supra-pharmacologic doses of intramuscular testosterone undecanoate do not increase aggressive behavior. But as stated before, testosterone can aromatize to estradiol. And there is considerable evidence among species, that estrogens, not testosterone, play a major role in aggression and hostility.
However, in studies conducted by Glaser and Dimitrakakis, over 90% of women treated with subcutaneous testosterone therapy have documented decreased aggression, irritability and anxiety. And this is not a new finding. Androgen therapy has been used to treat PMS for over 60 years.
Myth #9: It may increase the risk of breast cancer
It was recognized as early as 1937 that breast cancer was an estrogen sensitive cancer and that testosterone acted as a counter balance to estrogen. Clinical trials in primates and humans have confirmed that testosterone has a beneficial effect on breast tissue by decreasing breast proliferation and preventing stimulation from estradiol.
However, some epidemiological studies have reported an association between elevated androgens and breast cancer. But these studies suffer from methodological limitations, and more importantly, do not account for associated elevated estradiol levels and increased body mass index. And the cause and effect interpretation of these studies conflicts with the known biological effect of testosterone.
Although testosterone is breast protective, it can aromatize to estradiol and have a secondary, stimulatory effect on the estrogen receptor. But when testosterone is combined with an aromatase inhibitor in a subcutaneous implant, it blocks testosterone from aromatizing.
This form of treatment has been shown to effectively treat androgen deficiency symptoms in breast cancer survivors and is currently being evaluated in a U.S. national cancer study. In addition, Dimitrakakis and Glaser see a reduced incidence of breast cancer in women treated with testosterone or testosterone with anastrozole implants.
Myth #10: The safety of testosterone use in women has not been established
Testosterone implants have been used safely in women since 1938. Any real concerns would be well established by now.
Long-term data exists on the successful and safe use of testosterone in doses of up to 225 mg in up to 40 years of therapy. In addition, long term follow up studies on supra-pharmacologic doses used to 'female to male' transgender patients report no increase in mortality, breast cancer, vascular disease or other major health problems.
Many of the side effects and safety concerns attributed to testosterone are from oral formulations, or are secondary to increased aromatase activity due to elevated estradiol. This effect increases with age, obesity, alcohol intake, insulin resistance, breast cancer, medications, drugs, processed diet and sedentary lifestyle. Although often overlooked or not addressed in clinical studies, monitoring aromatase activity and symptoms of elevated estradiol is critical to the safe use of testosterone in both sexes.
Adequate testosterone is essential for physical, mental and emotional health in both sexes. Abandoning myths, misconceptions and unfounded concerns about testosterone and testosterone therapy in women allows physicians to provide evidence based recommendations and appropriate therapy
Weight Loss For Good - The 80-20 Rule!
Testosterone is a male hormone, besides promoting libido it has other important functions such as maintaining muscle mass and form bone, regulating heart muscle and cholesterol. It also helps to improve the oxygen levels throughout the body as well as controlling blood glucose and strengthening the immune system. In this article, we will discuss symptoms of low levels of testosterone.
1. Decreased sexual function
As we mentioned in the last article, starting at age 40 levels of testosterone start to diminish, the levels of the by-product prolactin of testosterone of men increases, stimulating the production of the enzyme 5-alpha reductase that causes the conversion of testosterone to gihydro-testosterones DHT thus triggering low levels of testosterone resulting in sexual dysfunction.
2. Loss of bone density
The brain and bone are the important tissues that have the primary effect of testosterone is by way of aromatization to 17² estradiol. In the bones. 17²-estradiol accelerates maturation of cartilage into bone, leading to closure of the epiphyses (a rounded end of a long bone) and conclusion of growth.
3. Loss of muscle mass
As men start aging or damage of pituitary gland or extra estrogen build up in the body causing low levels of testosterone being produced resulting in loss of muscle mass. Testosterone effects can be classified as anabolic effects that include growth of muscle mass and strength, increased bone density and strength, and stimulation of height growth and bone maturation. Testosterone effects can also be classified by the age of usual occurrence.
4. Memory loss
Low levels of testosterone allows beta-amyloid, a toxic peptide to accumulate in certain regions of the brain causing memory loss.
5. Abdominal fat
Fat cells create aromatase enzymes that contribute to fat build up and low levels of testosterone that allows the forming of abdominal fat that produce more aromatase enzyme resulting in more formation of estrogen. It also causes insulin resistance by increasing fat around the stomach/waist area and fat mass.
There are more symptoms of low levels of testosterone such as timidity, feeling of weakness, passive attitude,etc.
I hope this information will help. If you need more information of the above subject, please visit my home page.
Weight Loss For Good - The 80-20 Rule!
Marijuana attacks your precious testosterone in almost every negative way possible. One study after another has shown that cannabis lowers testosterone. For example one research team found that "a reanalysis of existing data established that testosterone levels are depressed both after smoking one marijuana cigarette and after intravenous infusion of delta-9-tetrahydrocannabinol, a pharmacologically active component of marijuana". The same study concluded that it would take at least 24 hours for testosterone levels to normalize after marijuana use. (NOTE: It's not just the smoke - an IV will do it.)
Another study found that not only was testosterone decreased after short term marijuana use, but leutenizing and follicle stimulating hormone were lowered as well. And just to add to the endocrinological misery, the arch-villain and stress hormone cortisol was raised as well. There are also studies in animals and humans that strongly indicate that marijuana blunts growth hormone response as well. And so it is no wonder that animal studies show that marijuana use shrinks the testes. So, if you're not happy with lowered testosterone, infertility and elevated cortisol, you can sit around enjoying the fact that you've got a little more air flow through your boxers.
You should also know that there are many reports that chronic marijuana use leads to gynecomastia, i.e. "enlarged male breasts", due to its abundant amounts of phytoestrogens. One journal writer pointed out that "given the effects of marijuana on the HPG axis in males and the possibility that noncannabinoid components of marijuana smoke have affinity to the estrogen receptor, an association with gynecomastia is plausible but has not been convincingly demonstrated". Remember that estrogen fights against testeosterone in the body as well.
Marijuana has also recently been flagged as particularly dangerous for young people because it decreases seratonin and increases norepineprine. While these are not sex hormones like testosterone, these can alter mood negatively and, through prolonged use, may permanently alter anxiety levels and reaction to stress. Again, the researchers are suggesting this may have long term, possibly lifetime anxiety and mood repercussions. I would also add that any increase in stress will also likely lower testosterone as well.
So we ask the question, "Could someone please explain again why anyone in their right mind would smoke marijuana?" The only thing we can think of is the extra hydrogen cyanide. That's right - marijuana tobaco is much higher in hydrogen cyanide - probably five times higher - than cigarette tobacco. Maybe that partially explains why habitual pot smoking is so hard on the lungs and why cannabis use has also now been linked to the most aggressive form of testicular cancer.
Not to make the bad news even worse, but there is also considerable reported evidence of erectile dysfunction among chronic marijuana users. This is undoubtedly partially due to the lowered testosterone. However, the other reason was discovered by one study that showed marijauna effected Nitric Oxide and summarized by saying, "We conclude that early endothelial damage may be induced by chronic cannabis use (and endocannabinoid system activation". Let me translate that: it may take your sex life with it. If so, decreased sexual activity is also associated with lowered testosterone levels as well.
The tragedy with marijuana is that many cultures and youth are embracing marijuana as more "natural", but this is far from being the case. One recent study found that marijuana induces just as much cell toxicity and DNA damage as cigarette smoke. The researchers were very clear that marijuana displayed just as much cancer causing power as the cigarette smoke: "In addition, when corrected for total particulate matter yield, little difference was observed in the mutagenic activity of samples smoked under the extreme vs the standard regime for both tobacco and marijuana condensates".
In summary, there is significant evidence that marijuana lowers testosterone, nitric oxide, leutinizing hormone, growth hormone and raises cortisol at the same time. Hormonally, there is no justifiable reason for cannabis use.
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South Bay, Florida
South Bay is a city in Palm Beach County, Florida, United States. It is the westernmost municipality in the South Florida metropolitan area. The population was 3,859 at the 2000 census. As of 2007, the population recorded by the U.S. Census Bureau was 4,506. While the current estimates place South Bay's population in the incorporated city limits at more than 4,000 people, surrounding areas increase the population figures to 54,000 people in a 25-mile (40 km) radius and more than 1.4 million in a 50-mile (80 km) radius.
South Bay was named for its location on Lake Okeechobee. The town was incorporated in 1941. The first mayor of South Bay was Aubrey (a.k.a. "Orb") Walker, who, along with his brother, Haughty D. Walker (a.k.a. "Haught"), survived the great hurricane of 1928 by gathering his family members onto a barge in the canal.
According to the United States Census Bureau, the city has a total area of 3.7 square miles (9.6 km2), including 2.7 square miles (7.0 km2) of land and 1.0 square mile (2.6 km2) of (26.95%) water. The Lake Okeechobee Scenic Trail runs through South Bay.