Are you one of the many people in Sunrise who are burning the candle at both ends and maybe only getting 4 or 5 hours of sleep a night? Are you also one of those guys having problems with his sex drive and feeling out of sorts? Well, recent studies done in Sunrise in the last 3 years show that these symptoms could all be due to the effect of sleep on testosterone – just how, though, may be a chicken and egg question!
While it’s true that lower testosterone levels can be the cause of a sluggish sex drive and irritability it seems to be a matter of research opinion whether low sleep levels cause low testosterone or low testosterone causes lack of sleep.
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Breast Cancer is the cancer that develops in the breast tissues mostly in the inner lining of milk ducts or in the lobules which supply milk to the ducts. Depending on the place of origination, they are known as ductal carcinoma, if originated in the milk ducts or lobular carcinoma when originated in the lobules. Breast cancers are also classified as hormone-positive or a hormone-negative cancer which is decided based on their sensitivity to hormones like progesterone and estrogen.
The options available for breast cancer treatment depend on the type of breast cancer and the staging results. Staging is the process in which the disease spread and its progressive extend is determined. Though it is the most common non-skin type of cancer in women and is considered one of the fatal types of cancer, there are many advanced breast cancer treatment options which can help cure this disease if detected early.
Breast Cancer Treatment Plan
Once the cancer has been diagnosed, the doctors evaluate the pathology report and form a plan that would suit the type of cancer and the stage to which the disease has progressed. Treatment modes aim at reducing the spread of the disease, destruction of the diseased cells and reduction of chances for re-occurrence in future. The doctors would choose a single or a set of treatment options based on the patient's medical conditions which they may evaluate periodically.
Types of Breast cancer treatment methods
The treatments available are in general classified as standard methods and clinical trial methods. Standard methods are those that are currently practised for the cure of breast cancer while clinical trials are those that are currently being tested for more efficient results. The standard methods of breast cancer treatment include surgery, hormone therapy, chemotherapy, radiation treatments and targeted therapy.
Surgical method of Breast Cancer Treatment
Surgery is one potential option for removing the cancerous cells from the body. The entire breast or a partial portion of the breast is removed depending on the level of spread and the stage to which the disease has progressed. Based on the level of operation that is required to remove the cancerous cells, the surgeries are differentiated into three types as below.
* Breast-conserving Surgery - This is an operation where only the portion of the breast that contains the cancer is removed and not the breast itself. If the surgery requires removal of just the tumor in the breast and a little amount of tissue, it is known as Lumpectomy or is known as Partial mastectomy if it includes removal of partial amount of the breast along with a considerable amount of normal tissues. These kinds of surgeries may also include removal of lymph nodes under the arm which are used for the purpose of biopsy. Such dissection done either along with the surgery or after it is known as lymph node dissection.
* Total Mastectomy - This kind of surgery targets on removing the whole breast which is infected with the cancerous cells. This also requires removal of lymph nodes for the purpose of biopsy.
* Modified radical Mastectomy - This is the surgery that removes extensive portions to get rid of the cancerous cells. The complete breast affected by cancer along with certain lymph nodes under the arm and the chest muscle lining is removed by this process of surgery. In certain cases, even part of the chest wall muscles that are affected are removed by this surgery.
* Radical Mastectomy - This surgery removes the complete breast, chest wall muscles and all the lymph nodes under the arm. This kind of surgery for breast cancer treatment is also known as Halsted radical mastectomy.
These surgeries can also be followed by other modes of breast cancer treatment methods like chemotherapy, hormone therapy or radiation therapy to kill any presence of cancer cells. Such kinds of treatment that helps in prevention of cancer re-occurrence is known as adjuvant therapy. Some patients can also consider the option of breast implants to rebuild the removed breast shape after a mastectomy.
This kind of treatment helps in killing the cancerous cells or prevents them from growing by means of internal administration of drugs. The way of drug administration can be either through the blood stream that spreads throughout the body which is known as systematic chemotherapy or is placed directly in the cerebrospinal fluid or any specific organ which is known as regional chemotherapy.
This kind of breast cancer treatment includes the introduction of substances that negate the effect of hormones which induce cancerous growth. Estrogen has been known to induce the growth of breast cancer in certain cases. One of the treatment methods includes prevention of ovaries from secreting the hormone estrogen and such a method is known as ovarian ablation. The hormonal therapy includes the usage of aromatase inhibitor which decreases the estrogen secretion in the body. Aromatase inhibitors are given for hormone-dependent breast cancer patients who are in postmenopausal stage while tamoxifen is used in cases of metastatic breast cancer. Aromatase inhibitors are also in general used as a means of adjuvant therapy after continued use of tamoxifen for two years or more.
High energy x-rays are in general used as an alternative for drugs to kill the cancer cells and prevent them from growing.
Another type of treatment that helps in destroying the cancer cells without any harm to the normal cells is called targeted therapy. The targeted therapies used in breast cancer treatment are in general of two types, Monoclonal antibodies and Tyrosine kinase inhibitors.
* Monoclonal Antibodies - These kinds of substances are antibodies that are made from a single type of immune system cell which has the potential to identify and destroy cancer cells. They are also sometimes used to carry toxins or drugs to the cancer cells to bring in effective destruction of the cells. Trastuzumab is a monoclonal antibody that is used in treating patients of breast cancer. This method can be clubbed along with chemotherapy as a means of adjuvant therapy.
* Tyrosine Kinase inhibitors - These drugs block signals that are needed for tumor growth and are in general used in combination with other anti-cancer drugs. Lapatjnib is one such inhibitor which helps block the HER2 protein inside the tumor cells and is used effectively for treatment of HER2- positive breast cancer patients.
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Marijuana attacks your precious testosterone in almost every negative way possible. One study after another has shown that cannabis lowers testosterone. For example one research team found that "a reanalysis of existing data established that testosterone levels are depressed both after smoking one marijuana cigarette and after intravenous infusion of delta-9-tetrahydrocannabinol, a pharmacologically active component of marijuana". The same study concluded that it would take at least 24 hours for testosterone levels to normalize after marijuana use. (NOTE: It's not just the smoke - an IV will do it.)
Another study found that not only was testosterone decreased after short term marijuana use, but leutenizing and follicle stimulating hormone were lowered as well. And just to add to the endocrinological misery, the arch-villain and stress hormone cortisol was raised as well. There are also studies in animals and humans that strongly indicate that marijuana blunts growth hormone response as well. And so it is no wonder that animal studies show that marijuana use shrinks the testes. So, if you're not happy with lowered testosterone, infertility and elevated cortisol, you can sit around enjoying the fact that you've got a little more air flow through your boxers.
You should also know that there are many reports that chronic marijuana use leads to gynecomastia, i.e. "enlarged male breasts", due to its abundant amounts of phytoestrogens. One journal writer pointed out that "given the effects of marijuana on the HPG axis in males and the possibility that noncannabinoid components of marijuana smoke have affinity to the estrogen receptor, an association with gynecomastia is plausible but has not been convincingly demonstrated". Remember that estrogen fights against testeosterone in the body as well.
Marijuana has also recently been flagged as particularly dangerous for young people because it decreases seratonin and increases norepineprine. While these are not sex hormones like testosterone, these can alter mood negatively and, through prolonged use, may permanently alter anxiety levels and reaction to stress. Again, the researchers are suggesting this may have long term, possibly lifetime anxiety and mood repercussions. I would also add that any increase in stress will also likely lower testosterone as well.
So we ask the question, "Could someone please explain again why anyone in their right mind would smoke marijuana?" The only thing we can think of is the extra hydrogen cyanide. That's right - marijuana tobaco is much higher in hydrogen cyanide - probably five times higher - than cigarette tobacco. Maybe that partially explains why habitual pot smoking is so hard on the lungs and why cannabis use has also now been linked to the most aggressive form of testicular cancer.
Not to make the bad news even worse, but there is also considerable reported evidence of erectile dysfunction among chronic marijuana users. This is undoubtedly partially due to the lowered testosterone. However, the other reason was discovered by one study that showed marijauna effected Nitric Oxide and summarized by saying, "We conclude that early endothelial damage may be induced by chronic cannabis use (and endocannabinoid system activation". Let me translate that: it may take your sex life with it. If so, decreased sexual activity is also associated with lowered testosterone levels as well.
The tragedy with marijuana is that many cultures and youth are embracing marijuana as more "natural", but this is far from being the case. One recent study found that marijuana induces just as much cell toxicity and DNA damage as cigarette smoke. The researchers were very clear that marijuana displayed just as much cancer causing power as the cigarette smoke: "In addition, when corrected for total particulate matter yield, little difference was observed in the mutagenic activity of samples smoked under the extreme vs the standard regime for both tobacco and marijuana condensates".
In summary, there is significant evidence that marijuana lowers testosterone, nitric oxide, leutinizing hormone, growth hormone and raises cortisol at the same time. Hormonally, there is no justifiable reason for cannabis use.
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It might be tempting to get a quick fix for hot flashes, but consider a different perimenopause treatment besides hormone replacement therapy (HRT). HRT may be inexpensive and easy, but its long-term risks outweigh the benefits - not to mention that it will likely further aggravate the symptoms of menopause! This outcome occurs because HRT causes estrogen dominance, a condition where there is far more estrogen than progesterone in the body. On the other hand, products that are natural for menopause-related symptoms will provide relief from your symptoms without causing estrogen dominance.
How is estrogen dominance related to traditional perimenopause treatments?
Estrogen dominance was a term coined by Dr. John Lee, the first doctor who published shocking findings on the dangers of HRT. His research was premised on the fact that a woman can experience serious health problems if she has normal or excessive estrogen, but little or no progesterone to balance out estrogen's effects on the body. Progesterone inhibits estrogen's effects on the body, e.g. when estrogen increases fat accumulation and weight gain, progesterone burns fat for energy. For these reasons, Dr. Lee suggested that giving progesterone supplements would benefit menopausal women more than estrogen-only HRT. However, his work was shunned by the medical community despite mounting evidence against HRT and the damage it causes. It's easy to see why - when Dr. Lee's research first came out in the 1980s, everyone was still caught up in the hype of estrogen HRT pushed by pharmaceutical companies.
Despite what you might be led to believe, HRT promotes unopposed estrogen. Women these days are very susceptible to becoming estrogen dominant, even when they are menopausal. The beauty products and cosmetics we use are laden with xenoestrogenic preservatives - manmade chemicals that behave like estrogen when they enter the body. Cows and chickens are also fed estrogen so they can grow and fatten up faster. On the other hand, we aren't exposed to the same levels of progesterone. Taking HRT will only skew the balance of estrogen and progesterone, causing estrogen dominance and increasing the risks of various health problems.
Risks of estrogen dominance caused by medications for perimenopause
Below are just some of the risks faced by menopausal women when they take HRT.
Increased menopause symptoms
While restoring your estrogen levels might reduce hot flashes initially, it may also cause increased weight gain, poor sleep patterns, headache, anxiety, and depression if left unopposed.
Fibrocystic breasts and breast cancer
Researchers from Harvard University discovered that the longer your exposure to estrogens, the greater your risk of fibrocystic breasts (breast cysts) and breast cancer. In their Nurses' Health Study, a study that tracked the health of 70,000 women for almost 20 years, they discovered that menopausal women who used estrogen had a 30% increased risk for breast cancer than women who didn't take HRT. The risk for breast cancer was 40% more among women who took estrogen and progestin (a manmade progesterone). Those who were taking HRT for over five years had an elevated risk that increased with their age. The Nurses' Health Study supports early evidence that HRT plays a significant role in the onset of breast cancer, even if progestin is added to balance out the estrogen.
Studies show that an increased risk of blood clots among menopausal women is triggered by two things: cigarette smoking and the use of synthetic estrogens.
Gallstones and liver problems
If you have a liver disorder, then you should definitely avoid HRT; estrogen affects the function of the liver enzymes. Research shows that women taking HRT have twice the risk of developing gallstones that require surgical removal.
Four to eight out of every one thousand menopausal women will develop uterine cancer because of HRT. Although the risk of uterine cancer is decreased when progestin is added, research shows that progestin will place you at risk for breast cancer. Other risk factors like cigarette smoking, a family history of uterine cancer, and abnormal uterine bleeding will also increase the likelihood of HRT-related uterine cancer despite the presence of progestin.
Unlike the symptoms of menopause, which are temporary, the side effects of HRT may last a lifetime. Avoid these risks and consider making lifestyle changes or using natural progesterone or phytoestrogens (plant estrogens) for perimenopause and menopause relief.
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Sunrise is a city in central-western Broward County, Florida, United States, in the Ft.Lauderdale metropolitan area. It was incorporated in 1961 by Norman Johnson – a developer whose Upside-Down House attracted buyers to what was then a remote area. As of the 2010 census, the city had a total population of 84,439. It is a principal city of the Miami metropolitan area, which was home to an estimated 6,012,331 people at the 2015 census.
In 1960, Iowa-born developer Norman Johnson paid $9 million for 2,650 acres of land in southwestern Broward County. By 1961, this community of 1.75 square miles – which Johnson named Sunrise Golf Village – had less than 350 residents.
It has been reported that the community was to be named Sunset Village – but this did not occur because of objections from residents who felt that "sunset" was too final. (Originally called "Sunset", the name did not sit well with the retirees whom developers wanted to attract, so a change was made to "Sunrise".)