Are you one of the many people in Westlake who are burning the candle at both ends and maybe only getting 4 or 5 hours of sleep a night? Are you also one of those guys having problems with his sex drive and feeling out of sorts? Well, recent studies done in Westlake in the last 3 years show that these symptoms could all be due to the effect of sleep on testosterone – just how, though, may be a chicken and egg question!
While it’s true that lower testosterone levels can be the cause of a sluggish sex drive and irritability it seems to be a matter of research opinion whether low sleep levels cause low testosterone or low testosterone causes lack of sleep.
Hormone Imbalance in Women
There's a growing interest in testosterone hormone replacement for treating symptoms related to aging. You've probably seen advertisements of virile, muscle bound men in their 60's and 70's.
Along with the growing interest there's also a growing amount of information. But much of it is anecdotal stories, misleading data and flat out, unproven myths. Especially as it relates to testosterone replacement therapy for women.
The fact is that medically administered, testosterone therapy is also used to successfully treat symptoms of hormone deficiency in pre and postmenopausal women. And two physicians-Dr. Rebecca Glaser and Dr. Constantine Dimitrakakis-are dispelling the misinformation about it through scientific research.
Dr. Glaser and Dr. Dimitrakakis focus on subcutaneously implanted, bio-identical hormones (human identical molecule) and not oral, synthetic androgens or anabolic steroids.
With that in mind, here are the 10 myths of testosterone replacement therapy for women.
Myth #1: Testosterone is a "male" hormone
Although men have a higher circulating level of testosterone than women, from a biological perspective, men and women are genetically similar. Both sexes include functional estrogen and androgen (testosterone) receptors. And while estrogen is popularly considered the primary female hormone, throughout a woman's lifespan, testosterone is actually the most abundant, biologically active hormone with significantly higher levels than estradiol. And as early as 1937, testosterone therapy was reported to effectively treat symptoms of the menopause.
Myth #2: Its only role in women is sex drive and libido
There's a lot of hype about testosterone's role in sexual function. But in reality, it's a fraction of the overall physiologic effect testosterone plays in women. That's because testosterone governs the health of almost all tissues including the breast, heart, blood vessels, gastrointestinal tract, lung, brain, spinal cord, peripheral nerves, bladder, uterus, ovaries, endocrine glands, vaginal tissue, skin, bone, bone marrow, synovium, muscle and adipose tissue.
The function of these tissues declines as testosterone declines. The result of this deficiency in both men and women includes dysphoric mood (anxiety, irritability, depression), lack of well-being, physical fatigue, bone loss, muscle loss, changes in cognition, memory loss, insomnia, hot flashes, rheumatoid complaints, pain, breast pain, urinary complaints, incontinence as well as sexual dysfunction. And just like for men, these symptoms are successfully treated in women through testosterone therapy.
Myth #3: It masculinizes females
Testosterone therapy has been safely and successfully administered in women for over 76 years. Rather than decrease a woman's femininity it increases it. Testosterone stimulates ovulation, increases fertility and safely treats the nausea of early pregnancy without adverse effects.
Sure, large doses of supra-pharmacological synthetic testosterone are used to treat female to male transgender patients to increase male traits like body hair. But this requires high doses over an extended period of time. Even then, true masculinization is still not possible. And these effects are reversible by simply lowering the dosage.
Myth #4: It causes hoarseness and voice changes
Hoarseness is most commonly caused by inflammation due to allergies, infectious or chemical laryngitis, reflux esophagitis, voice over-use, mucosal tears, medications and vocal cord polyps. Testosterone possesses anti-inflammatory properties. There is no evidence that testosterone causes hoarseness and there is no physiological mechanism that allows testosterone to do so.
Although a few anecdotal case reports and small questionnaire studies have reported an association between 400 and 800 mg/d of danazol and self-reported, subjective voice 'changes' an objective study demonstrated the opposite.
Twenty-four patients received 600 mg of danazol (synthetic testosterone) therapy daily and were studied for 3 and 6 months. There were no vocal changes that could be attributed to the androgenic properties of danazol. These conclusions are consistent with a one year study examining voice changes on pharmaco-logic doses of subcutaneous testosterone implant therapy in women by Glaser and Dimitrakakis.
Myth #5: It causes hair loss
Hair loss is a complicated, genetically determined process and there is no evidence that either testosterone or testosterone therapy cause it. In fact, from a medical perspective, dihy-drotestosterone (DHT), not testosterone, is considered the active androgen in male pattern balding.
There are many factors associated with hair loss. For example, it's common in both women and men with insulin resistance. Insulin resistance increases 5-alpha reductase, which increases conversion of testosterone to dihy-drotestosterone in the hair follicle.
In addition, obesity, age, alcohol, medications and sedentary lifestyle increase aromatase activity, which lowers testosterone and raises estradiol. Increased DHT, lowered testosterone, and elevated estradiol levels can contribute to hair loss in genetically predisposed men and women. But so can medications, stress and nutritional deficiencies.
In studies conducted by Glaser and Dimitrakakis, two thirds of women treated with subcutaneous testosterone implants have scalp hair re-growth on therapy. Women who did not re-grow hair were more likely to be hypo or hyperthyroid, iron deficient or have elevated body mass index. And none of the 285 patients treated for up to 56 months with subcutaneous T therapy complained of hair loss.
Myth #6: It has adverse effects on the heart
On the contrary, there is overwhelming biological and clinical evidence that testosterone promotes a healthy heart. Testosterone has a beneficial effect on lean body mass, glucose metabolism and lipid profiles in men and women. It is successfully used to treat and prevent cardiovascular disease and diabetes.
Testosterone also widens blood vessels in both sexes, has immune-modulating properties that inhibit plaque and strengthens the cardiac muscle. It improves functional capacity, insulin resistance and muscle strength in both men and women with congestive heart failure.
Myth #7: It causes liver damage
High doses of oral, synthetic androgens (e.g., methyl-testosterone) pass through the digestive system, are absorbed into the entero-hepatic circulation and can adversely affect the liver. But subcutaneous implants and topical patches avoid the entero-hepatic circulation and bypass the liver. So there is no adverse effect on the liver, liver enzymes or clotting factors.
Furthermore, non-oral testosterone does not increase the risk of deep venous thrombosis or pulmonary embolism like oral estrogens, androgens and synthetic progestins. And despite the concern over liver toxicities with anabolic steroids and oral synthetic androgens, there are only 3 reports of hepa-tocellular carcinoma in men treated with high doses of oral synthetic methyl testosterone. Even the report of benign tumors (adenomas) with oral androgen therapy is exceedingly rare.
Myth #8: It causes aggression
Although anabolic steroids can increase aggression and rage, this does not occur with testosterone therapy. Even supra-pharmacologic doses of intramuscular testosterone undecanoate do not increase aggressive behavior. But as stated before, testosterone can aromatize to estradiol. And there is considerable evidence among species, that estrogens, not testosterone, play a major role in aggression and hostility.
However, in studies conducted by Glaser and Dimitrakakis, over 90% of women treated with subcutaneous testosterone therapy have documented decreased aggression, irritability and anxiety. And this is not a new finding. Androgen therapy has been used to treat PMS for over 60 years.
Myth #9: It may increase the risk of breast cancer
It was recognized as early as 1937 that breast cancer was an estrogen sensitive cancer and that testosterone acted as a counter balance to estrogen. Clinical trials in primates and humans have confirmed that testosterone has a beneficial effect on breast tissue by decreasing breast proliferation and preventing stimulation from estradiol.
However, some epidemiological studies have reported an association between elevated androgens and breast cancer. But these studies suffer from methodological limitations, and more importantly, do not account for associated elevated estradiol levels and increased body mass index. And the cause and effect interpretation of these studies conflicts with the known biological effect of testosterone.
Although testosterone is breast protective, it can aromatize to estradiol and have a secondary, stimulatory effect on the estrogen receptor. But when testosterone is combined with an aromatase inhibitor in a subcutaneous implant, it blocks testosterone from aromatizing.
This form of treatment has been shown to effectively treat androgen deficiency symptoms in breast cancer survivors and is currently being evaluated in a U.S. national cancer study. In addition, Dimitrakakis and Glaser see a reduced incidence of breast cancer in women treated with testosterone or testosterone with anastrozole implants.
Myth #10: The safety of testosterone use in women has not been established
Testosterone implants have been used safely in women since 1938. Any real concerns would be well established by now.
Long-term data exists on the successful and safe use of testosterone in doses of up to 225 mg in up to 40 years of therapy. In addition, long term follow up studies on supra-pharmacologic doses used to 'female to male' transgender patients report no increase in mortality, breast cancer, vascular disease or other major health problems.
Many of the side effects and safety concerns attributed to testosterone are from oral formulations, or are secondary to increased aromatase activity due to elevated estradiol. This effect increases with age, obesity, alcohol intake, insulin resistance, breast cancer, medications, drugs, processed diet and sedentary lifestyle. Although often overlooked or not addressed in clinical studies, monitoring aromatase activity and symptoms of elevated estradiol is critical to the safe use of testosterone in both sexes.
Adequate testosterone is essential for physical, mental and emotional health in both sexes. Abandoning myths, misconceptions and unfounded concerns about testosterone and testosterone therapy in women allows physicians to provide evidence based recommendations and appropriate therapy
Hormone Imbalance in Women
Theoretically, menopause is not a disease. Therefore, there is no cure. Many women opt to forgo any treatment at all, and simply tolerate many of the symptoms associated with this normal transition. However, for those women whose symptoms are so severe as to interfere with their quality of life, there are many options at their disposal.
Remedies may be implemented by the woman herself for the conditions associated with menopause. For example,
Hot flashes: Several nonprescription treatments are available, and lifestyle choices can help.
- Many women feel that regular aerobic exercise can help reduce hot flashes
- Foods that may trigger hot flashes, such as spicy foods, caffeine, and alcohol, should be avoided.
Weight gain: Regular exercise is helpful in controlling weight.
Osteoporosis: Adequate calcium intake and weight-bearing exercise are important. Strength training (lifting weights or using exercise bands in resistance training) can strengthen bones.
Certain medications are beneficial in reducing many of the signs and symptoms of menopause.
Hormone Replacement Therapy
- estrogen or a combination of estrogen and progestin
- treats hot flashes
- reduce fracture risk by building bone mass
- improve cholesterol levels
- decrease vaginal dryness
- estrogen and progestin combination associated with increased risk of heart attack, stroke, and breast cancer
- estrogen alone associated with increased risk of endometrial cancer
- increased risk of gallstones and blood clots
- normally used for depression and anxiety
- effective in reducing hot flashes
- used to lower blood pressure
- effective in reducing hot flashes
- primarily used for treating seizures
- used to treat hot flashes
- short-term relief of hot flashes
- not recommended as first-line drug
- sometimes effective in treating hot flashes
- may cause weight gain and bone loss
- Aldenodrate (Fosamax)
- Raloxifene (Evista)
- Calcitonin (Calcimar or Miacalcin)
- herbal supplement
- German studies recommend limiting its use to six months or less
- not regulated by the Food and Drug Administration
- side effects include nausea, vomiting, dizziness, visual problems, slow heart beat, and excessive sweating
- soy is an example
- safety of soy in women with breast cancer not established
- dong quai
- red clover
- yam cream
- Chinese medicinal herbs
- evening primrose oil
Perimenopause Treatment - Beware of HRT
Women have different weight loss needs than men. Many times, men seem to lose weight at the drop of a hat, while women seem to starve themselves for weeks, only to find that they have only lost a pound. Is there a way to even the playing field in the weight loss game? Sure there is! By following weight loss advice designed for women, women can lose just as much weight as men can in the same amount of time.
One reason men seem to lose weight faster than women is because of a nasty little visitor that women have that drops by once a month. While your period doesn't actually cause lasting weight gain, it does cause you to temporarily gain water weight. Water weight can stick on you for two weeks at a time, causing you to feel like your weight loss efforts are not doing any good at all. This may cause you to give up on them altogether. Your period can also make you feel pretty bad. With irritability, cramps, headaches and bloating, you may have moments of weakness and grab that brownie that has been calling your name. Then you might feel worse, and eat the whole pan of brownies.
Men, obviously don't have these problems, the lucky punks. To combat these issues, there are some tricks you can try. To fight the bloating, resist the urge to chug soft drinks and chomp down the potato chips. The extra sugar, carbonation and other nasty ingredients in soda can make you feel bloated and tired. Chips have a lot of sodium and grease, which can add to the bloat. To help with the cramps and headaches, talk to your doctor about a gentle pain reliever that will work for you. Also, drinking warm tea will help you feel better. When it comes to cravings, remember chocolate is not your enemy. Sounds crazy, I know, but it isn't all the fat and sugar that comes with some chocolate that you are craving it is the chocolate itself. Find a chocolate bar that has the highest concentration of cocoa. You will need less of this chocolate bar to satisfy your cravings. Using these tips will help you relax, feel better, and not give up or de-rail your weight loss efforts.
One advantage that women have over men in the weight loss battle is soy. Soy is not good for men in large amounts because of the phyto-estrogens it contains. These phyto-estrogens don't have ill effects on women, so women can enjoy more soy, and it can actually be a healthy addition to their diets. There are many yummy products that include soy, and soy can be a great low-fat way to get in your protein. So is a part of many products these days, so you can choose from a variety of tasty products.
When it comes to weight loss, women often think that men have the upper hand. Once you understand the reason why women have a harder time losing weight, you can prevent these issues and take advantage of the benefits that soy has to offer. Women can improve their weight loss odds by following these tricks designed especially for women.
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The Miami metropolitan area, also known as the Greater Miami Area or South Florida, is the 73rd largest metropolitan area in the world and the eighth-largest metropolitan area in the United States. It is entirely in the southern portion of the U.S. state of Florida. With 6,158,824 inhabitants as of 2017, the Miami metropolitan area is the most populous in Florida and second largest in the southeastern United States.
The metropolitan area is defined by the Office of Management and Budget as the Miami–Fort Lauderdale–West Palm Beach, FL (MSA), consisting of Miami-Dade, Broward, and Palm Beach counties, a metropolitan statistical area used for statistical purposes by the United States Census Bureau and other agencies. Its land area is 6,137 sq. mi (15,890 km2).
Miami-Dade, Broward, and Palm Beach counties are the first, second, and third most populous counties in Florida, and Miami-Dade, with 2,751,796 people in 2017, is the seventh most populous county in the United States. The three counties together have principal cities including Miami, Fort Lauderdale, Pompano Beach, West Palm Beach, and Boca Raton. Besides its association with the South Florida region, is also partially synonymous with an area known collectively as the "Gold Coast".