Are you one of the many people in PBG who are burning the candle at both ends and maybe only getting 4 or 5 hours of sleep a night? Are you also one of those guys having problems with his sex drive and feeling out of sorts? Well, recent studies done in PBG in the last 3 years show that these symptoms could all be due to the effect of sleep on testosterone – just how, though, may be a chicken and egg question!
While it’s true that lower testosterone levels can be the cause of a sluggish sex drive and irritability it seems to be a matter of research opinion whether low sleep levels cause low testosterone or low testosterone causes lack of sleep.
Testosterone Replacement Therapy or a Testosterone Booster?
There's a growing interest in testosterone hormone replacement for treating symptoms related to aging. You've probably seen advertisements of virile, muscle bound men in their 60's and 70's.
Along with the growing interest there's also a growing amount of information. But much of it is anecdotal stories, misleading data and flat out, unproven myths. Especially as it relates to testosterone replacement therapy for women.
The fact is that medically administered, testosterone therapy is also used to successfully treat symptoms of hormone deficiency in pre and postmenopausal women. And two physicians-Dr. Rebecca Glaser and Dr. Constantine Dimitrakakis-are dispelling the misinformation about it through scientific research.
Dr. Glaser and Dr. Dimitrakakis focus on subcutaneously implanted, bio-identical hormones (human identical molecule) and not oral, synthetic androgens or anabolic steroids.
With that in mind, here are the 10 myths of testosterone replacement therapy for women.
Myth #1: Testosterone is a "male" hormone
Although men have a higher circulating level of testosterone than women, from a biological perspective, men and women are genetically similar. Both sexes include functional estrogen and androgen (testosterone) receptors. And while estrogen is popularly considered the primary female hormone, throughout a woman's lifespan, testosterone is actually the most abundant, biologically active hormone with significantly higher levels than estradiol. And as early as 1937, testosterone therapy was reported to effectively treat symptoms of the menopause.
Myth #2: Its only role in women is sex drive and libido
There's a lot of hype about testosterone's role in sexual function. But in reality, it's a fraction of the overall physiologic effect testosterone plays in women. That's because testosterone governs the health of almost all tissues including the breast, heart, blood vessels, gastrointestinal tract, lung, brain, spinal cord, peripheral nerves, bladder, uterus, ovaries, endocrine glands, vaginal tissue, skin, bone, bone marrow, synovium, muscle and adipose tissue.
The function of these tissues declines as testosterone declines. The result of this deficiency in both men and women includes dysphoric mood (anxiety, irritability, depression), lack of well-being, physical fatigue, bone loss, muscle loss, changes in cognition, memory loss, insomnia, hot flashes, rheumatoid complaints, pain, breast pain, urinary complaints, incontinence as well as sexual dysfunction. And just like for men, these symptoms are successfully treated in women through testosterone therapy.
Myth #3: It masculinizes females
Testosterone therapy has been safely and successfully administered in women for over 76 years. Rather than decrease a woman's femininity it increases it. Testosterone stimulates ovulation, increases fertility and safely treats the nausea of early pregnancy without adverse effects.
Sure, large doses of supra-pharmacological synthetic testosterone are used to treat female to male transgender patients to increase male traits like body hair. But this requires high doses over an extended period of time. Even then, true masculinization is still not possible. And these effects are reversible by simply lowering the dosage.
Myth #4: It causes hoarseness and voice changes
Hoarseness is most commonly caused by inflammation due to allergies, infectious or chemical laryngitis, reflux esophagitis, voice over-use, mucosal tears, medications and vocal cord polyps. Testosterone possesses anti-inflammatory properties. There is no evidence that testosterone causes hoarseness and there is no physiological mechanism that allows testosterone to do so.
Although a few anecdotal case reports and small questionnaire studies have reported an association between 400 and 800 mg/d of danazol and self-reported, subjective voice 'changes' an objective study demonstrated the opposite.
Twenty-four patients received 600 mg of danazol (synthetic testosterone) therapy daily and were studied for 3 and 6 months. There were no vocal changes that could be attributed to the androgenic properties of danazol. These conclusions are consistent with a one year study examining voice changes on pharmaco-logic doses of subcutaneous testosterone implant therapy in women by Glaser and Dimitrakakis.
Myth #5: It causes hair loss
Hair loss is a complicated, genetically determined process and there is no evidence that either testosterone or testosterone therapy cause it. In fact, from a medical perspective, dihy-drotestosterone (DHT), not testosterone, is considered the active androgen in male pattern balding.
There are many factors associated with hair loss. For example, it's common in both women and men with insulin resistance. Insulin resistance increases 5-alpha reductase, which increases conversion of testosterone to dihy-drotestosterone in the hair follicle.
In addition, obesity, age, alcohol, medications and sedentary lifestyle increase aromatase activity, which lowers testosterone and raises estradiol. Increased DHT, lowered testosterone, and elevated estradiol levels can contribute to hair loss in genetically predisposed men and women. But so can medications, stress and nutritional deficiencies.
In studies conducted by Glaser and Dimitrakakis, two thirds of women treated with subcutaneous testosterone implants have scalp hair re-growth on therapy. Women who did not re-grow hair were more likely to be hypo or hyperthyroid, iron deficient or have elevated body mass index. And none of the 285 patients treated for up to 56 months with subcutaneous T therapy complained of hair loss.
Myth #6: It has adverse effects on the heart
On the contrary, there is overwhelming biological and clinical evidence that testosterone promotes a healthy heart. Testosterone has a beneficial effect on lean body mass, glucose metabolism and lipid profiles in men and women. It is successfully used to treat and prevent cardiovascular disease and diabetes.
Testosterone also widens blood vessels in both sexes, has immune-modulating properties that inhibit plaque and strengthens the cardiac muscle. It improves functional capacity, insulin resistance and muscle strength in both men and women with congestive heart failure.
Myth #7: It causes liver damage
High doses of oral, synthetic androgens (e.g., methyl-testosterone) pass through the digestive system, are absorbed into the entero-hepatic circulation and can adversely affect the liver. But subcutaneous implants and topical patches avoid the entero-hepatic circulation and bypass the liver. So there is no adverse effect on the liver, liver enzymes or clotting factors.
Furthermore, non-oral testosterone does not increase the risk of deep venous thrombosis or pulmonary embolism like oral estrogens, androgens and synthetic progestins. And despite the concern over liver toxicities with anabolic steroids and oral synthetic androgens, there are only 3 reports of hepa-tocellular carcinoma in men treated with high doses of oral synthetic methyl testosterone. Even the report of benign tumors (adenomas) with oral androgen therapy is exceedingly rare.
Myth #8: It causes aggression
Although anabolic steroids can increase aggression and rage, this does not occur with testosterone therapy. Even supra-pharmacologic doses of intramuscular testosterone undecanoate do not increase aggressive behavior. But as stated before, testosterone can aromatize to estradiol. And there is considerable evidence among species, that estrogens, not testosterone, play a major role in aggression and hostility.
However, in studies conducted by Glaser and Dimitrakakis, over 90% of women treated with subcutaneous testosterone therapy have documented decreased aggression, irritability and anxiety. And this is not a new finding. Androgen therapy has been used to treat PMS for over 60 years.
Myth #9: It may increase the risk of breast cancer
It was recognized as early as 1937 that breast cancer was an estrogen sensitive cancer and that testosterone acted as a counter balance to estrogen. Clinical trials in primates and humans have confirmed that testosterone has a beneficial effect on breast tissue by decreasing breast proliferation and preventing stimulation from estradiol.
However, some epidemiological studies have reported an association between elevated androgens and breast cancer. But these studies suffer from methodological limitations, and more importantly, do not account for associated elevated estradiol levels and increased body mass index. And the cause and effect interpretation of these studies conflicts with the known biological effect of testosterone.
Although testosterone is breast protective, it can aromatize to estradiol and have a secondary, stimulatory effect on the estrogen receptor. But when testosterone is combined with an aromatase inhibitor in a subcutaneous implant, it blocks testosterone from aromatizing.
This form of treatment has been shown to effectively treat androgen deficiency symptoms in breast cancer survivors and is currently being evaluated in a U.S. national cancer study. In addition, Dimitrakakis and Glaser see a reduced incidence of breast cancer in women treated with testosterone or testosterone with anastrozole implants.
Myth #10: The safety of testosterone use in women has not been established
Testosterone implants have been used safely in women since 1938. Any real concerns would be well established by now.
Long-term data exists on the successful and safe use of testosterone in doses of up to 225 mg in up to 40 years of therapy. In addition, long term follow up studies on supra-pharmacologic doses used to 'female to male' transgender patients report no increase in mortality, breast cancer, vascular disease or other major health problems.
Many of the side effects and safety concerns attributed to testosterone are from oral formulations, or are secondary to increased aromatase activity due to elevated estradiol. This effect increases with age, obesity, alcohol intake, insulin resistance, breast cancer, medications, drugs, processed diet and sedentary lifestyle. Although often overlooked or not addressed in clinical studies, monitoring aromatase activity and symptoms of elevated estradiol is critical to the safe use of testosterone in both sexes.
Adequate testosterone is essential for physical, mental and emotional health in both sexes. Abandoning myths, misconceptions and unfounded concerns about testosterone and testosterone therapy in women allows physicians to provide evidence based recommendations and appropriate therapy
Various Menopause Treatment Options
Are You Curious About Testosterone Therapy?
The subject of testosterone therapy has caught my attention lately. I had begun to study about it when about three or four months ago my wife brought me a bottle of testosterone capsules for a 90-day trial. She wanted to see if it would help me in my battle with afternoon fatigue and general lethargy.
I thought why not, it can't hurt. I wasn't desperate or anything, I was mostly curious about "Low-T" and wanted to experience for myself all these health claims that are flying around the media lately. For example, these TV commercials about the cure for erectile dysfunction were getting on my nerves. I am particularly dismayed by the couple in two separate bathtubs. What's up with that? (Sorry no pun intended).
Then a few days ago I got a call from a telemarketer, asking how my testosterone trial was going. I told him it was working great for keeping elephants out of my flower beds. As long as I was taking the capsules, no elephants had trampled my flowers. He was not impressed by my humor, and just wanted to get me to order more. Nope, I told him. I really couldn't tell any difference on or off the capsules. When he told me I needed more time for my body to adjust to the product, I ended the conversation. I know more about Low T after my extensive research than he seemed to know
On the other hand, someone is buying this stuff. In an article by Rachael Rettner, (published on line on MyHealthNewsDaily June 3, 2013, Copyright © 2013 TechMediaNetwork.com). Ms. Rettner says, "The percentage of middle-aged men in the United States taking testosterone to treat symptoms of low testosterone, or "low T," has increased substantially in recent years, a new study suggests."
For the last ten years, prescriptions for testosterone supplements among men over age 40 has been gradually increasing until today more than 3% of men in that age bracket have received some form of testosterone therapy. That is almost three times more than in 2001.
But does the stuff work? The answer is that study results have been less than supportive that it does. In fact, I found many so-called scientific studies that made all sorts of weird claims, but none were truly conclusive. It is like my-elephant-in-the-flowerbed comment. The obvious sarcasm is that if I did nothing, the elephants wouldn't bother me because I don't have any elephants wandering around my suburb. Scientific research cannot prove a hypothesis by the absence of symptoms.
Ms Rettner presented her most shocking comment when she quoted an editorial by Dr. Lisa Schwartz and Dr. Steven Woloshin, of the Dartmouth Institute for Health Policy & Clinical Practice: "the low T campaign [is] "a mass, uncontrolled experiment that invites men to expose themselves to the harms of a treatment unlikely to fix problems that may be wholly unrelated to testosterone levels."
"Before anyone makes millions of men aware of low T, they should be required to do a large-scale randomized trial to demonstrate that testosterone therapy for healthy aging men does more good than harm," they wrote.
By Dr. Luke Aaronson, PhD
Weight Loss Consequences, Physical or Emotional?
Have you ever considered following a weight loss process, if you have then chances are that most people tell you about how simple, easy, and utterly accessible it is; however you will hardly hear about the negative consequences that it may provoke in your physical and mental self, which is why this article is meant to be a source of information for all of those people who are not quite sure of their decision yet, and have to learn about the various weight loss consequences that they can expect.
First of all let me tell you that weight loss is truly simple, it is just a matter of willpower and dedication, that is it. Just lay back on the amount of calories you take, practice some exercise, and dedicate yourself to your body a little more than you used to. However the weight loss consequences for following these advices are not always so easy to handle, they mean cutting off your favorite drinks, meals and deserts. It also means that you will have less time to do the things that you enjoy the most, and here is exactly where these weight loss consequences come into play.
You will probably feel depressed for a while when following a weight loss method, especially if you do not start seeing results fast. What happens is that you start thinking if all that sacrifice is really worth it, seeing that you have only lost a few pounds, what's the point of all these weight loss efforts anyway? But you need to be consistent, if you drop your efforts by the moment you start thinking about that, then you will lose all progress, which means that your weight loss motivation will be as good as gone.
Weight loss consequences are not physical at all; some people suffer from different minor problems at first, but only those who follow a starving diet or an overwhelming weight loss exercise routine. If you take your time and pace yourself, there is no possible danger that you may suffer, but the weight loss consequences may present themselves in the form of mental problems.
In order to avoid these weight loss consequences, just remember that you are following the process in order to become a healthier person, remember the very reasons why you decided to follow the methods in the first place, and have a lot of faith in the upcoming results, I can guarantee that they will be worth your time.
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Plattsburgh International Airport
Plattsburgh International Airport (IATA: PBG, ICAO: KPBG, FAA LID: PBG) is a county public use airport located three nautical miles (6 km) south of the central business district of Plattsburgh, a city in Clinton County, New York, United States.
The airport is located at the former Plattsburgh Air Force Base and has been owned by Clinton County since 2002. The old base is still being redeveloped by Plattsburgh Airbase Redevelopment Corporation, established in 1995 after the airbase closed. The airport's massive facilities have been upgraded to civilian aviation standards and the county fully transitioned here from Clinton County Airport as of June 2007.
Passenger service began on June 18, 2007 and Clinton County Airport has been shut down since then. All airline service in Plattsburgh goes through the airport and is in the process of beginning to expand its terminal building to accommodate more passengers and provide more gates for aircraft. Scheduled passenger service to Boston at this airport is subsidized by the United States Department of Transportation via the Essential Air Service program.